Development and Evaluation of a Simulation-Based Algorithm to Optimize the Planning of Interim Analyses for Clinical Trials in ALS.

van Unnik JWJ, Nikolakopoulos S, Eijkemans MJC, Gonzalez-Bermejo J, Bruneteau G, Morelot-Panzini C, van den Berg LH, Cudkowicz ME, McDermott CJ, Similowski T, van Eijk RPA; DiPALS, RespiStimALS and Ceftriaxone Study Group.